anti kdm6a d3q1i rabbit antibody (Cell Signaling Technology Inc)
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Cell Signaling Technology Inc
anti kdm6a d3q1i rabbit antibody
Anti Kdm6a D3q1i Rabbit Antibody, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 95/100, based on 126 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/kdm6a+antibody/UTX+Rabbit+mAb/pmc13003410-122-0-5
Average 95 stars, based on 126 article reviews
Anti Kdm6a D3q1i Rabbit Antibody, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 95/100, based on 126 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/kdm6a+antibody/UTX+Rabbit+mAb/pmc13003410-122-0-5
Average 95 stars, based on 126 article reviews
anti kdm6a d3q1i rabbit antibody - by Bioz Stars,
2026-09
95/100 stars
Images
1) Product Images from "Distinct contributions of Etv2 + and Flk1 + progenitors to endothelial, hematopoietic, and cardiac lineages"
Article Title: Distinct contributions of Etv2 + and Flk1 + progenitors to endothelial, hematopoietic, and cardiac lineages
Journal: Cell reports
doi: 10.1016/j.celrep.2025.116733
Figure Legend Snippet: (A) Immunoprecipitation followed by western blotting analysis showing ETV2 and BAF155 association with BRG1, UTX ( Kdm6a ), and EP300. (B) Analysis of PDGFRα and FLK1 expression in day 4 wild-type and Baf155-KO EBs. The frequencies of DP and SP generation are quantified and shown. The data are represented as the average ± standard deviation. The significance of data was determined using an unpaired t test. (C) ETV2 ChIP sequencing peaks (highlighted) nearest the candidate target hemangiogenic genes. (D) ChIP-qPCR analysis showing BAF155 binding at ETV2 target loci. (E) ChIP-qPCR analysis showing ETV2 binding at target loci in wild-type and Baf155-KO EB cells. The data are represented as the average ± standard deviation. The significance of data was determined using an unpaired t test. (F) Expression of ETV2-regulated genes in wild-type and Baf155 -KO EB cells determined by RT-qPCR and normalized to β-actin housekeeping gene expression. The data are represented as the average ± standard deviation. The significance of data was determined using one-way ANOVA. (G) Hematopoietic colony-forming assays performed using day 4 wild-type and Baf155 EBs. The number of hematopoietic colonies formed is shown. The data are represented as the average ± standard deviation. The significance of data was determined using an unpaired t test. (H) Hematopoietic colony-forming assays performed using ~E8.5 Baf155 Δ Flk -cKO and control embryos. The number of BFU-E (erythroid) and myeloid colonies generated is shown. The data are represented as the average ± standard deviation. The significance of data was determined using an unpaired t test. (I) Hematopoietic colony-forming assays performed using ~E8.5 Baf155 Δ Etv2 -cKO and control embryos. The number of BFU-E (erythroid) and myeloid colonies generated is shown. The data are represented as the average ± standard deviation. The significance of data was determined using an unpaired t test. Significance of data: * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001, and ns, non-significant.
Techniques Used: Immunoprecipitation, Western Blot, Expressing, Standard Deviation, ChIP-sequencing, ChIP-qPCR, Binding Assay, Quantitative RT-PCR, Gene Expression, Control, Generated
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Article Snippet: Following antibodies were used: pmTOR, mTOR, pS6, S6 kinase, KDM4B, Histone 3, cleaved PARP1, KDM6A, and ChIP-qPCR:Article Title: Regulation of Epigenetic Modifiers, Including KDM6B, by Interferon-γ and Interleukin-4 in Human Macrophages Article Snippet: The antibodies used were Phospho-Rb-Ser807/811, E2F1, KDM6A, and Article Title: Epigenetic regulation of CD38/CD48 by KDM6A mediates NK cell response in multiple myeloma Article Snippet: If you are not sure if a list item applies to your research, read the appropriate section before selecting a response. ary April 2023 Materials & experimental systems n/a Involved in the study Antibodies Eukaryotic cell lines Palaeontology and archaeology Animals and other organisms Clinical data Dual use research of concern Plants Methods n/a Involved in the study ChIP-seq Flow cytometry MRI-based neuroimaging Antibodies Antibodies used Antibodies were obtained as follows: Article Title: Coordinated regulation of chromatin modifiers reflects organised epigenetic programming in mouse oocytes Article Snippet: KDM6A , Rabbit , 1:400 , Validated in Article Title: Therapeutic targeting of histone lysine demethylase KDM4B blocks the growth of castration-resistant prostate cancer. 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Article Snippet: Following antibodies were used: pmTOR, mTOR, pS6, S6 kinase, KDM4B, Histone 3, cleaved PARP1, KDM6A, and Luciferase:Article Title: Regulation of Epigenetic Modifiers, Including KDM6B, by Interferon-γ and Interleukin-4 in Human Macrophages Article Snippet: The antibodies used were Phospho-Rb-Ser807/811, E2F1, KDM6A, and Article Title: Epigenetic regulation of CD38/CD48 by KDM6A mediates NK cell response in multiple myeloma Article Snippet: If you are not sure if a list item applies to your research, read the appropriate section before selecting a response. ary April 2023 Materials & experimental systems n/a Involved in the study Antibodies Eukaryotic cell lines Palaeontology and archaeology Animals and other organisms Clinical data Dual use research of concern Plants Methods n/a Involved in the study ChIP-seq Flow cytometry MRI-based neuroimaging Antibodies Antibodies used Antibodies were obtained as follows: Article Title: Coordinated regulation of chromatin modifiers reflects organised epigenetic programming in mouse oocytes Article Snippet: KDM6A , Rabbit , 1:400 , Validated in Article Title: Therapeutic targeting of histone lysine demethylase KDM4B blocks the growth of castration-resistant prostate cancer. Article Snippet: Following antibodies were used: pmTOR, mTOR, pS6, S6 kinase, KDM4B, Histone 3, cleaved PARP1, KDM6A, and Synthesized:Article Title: Regulation of Epigenetic Modifiers, Including KDM6B, by Interferon-γ and Interleukin-4 in Human Macrophages Article Snippet: The antibodies used were Phospho-Rb-Ser807/811, E2F1, KDM6A, and Article Title: Epigenetic regulation of CD38/CD48 by KDM6A mediates NK cell response in multiple myeloma Article Snippet: If you are not sure if a list item applies to your research, read the appropriate section before selecting a response. ary April 2023 Materials & experimental systems n/a Involved in the study Antibodies Eukaryotic cell lines Palaeontology and archaeology Animals and other organisms Clinical data Dual use research of concern Plants Methods n/a Involved in the study ChIP-seq Flow cytometry MRI-based neuroimaging Antibodies Antibodies used Antibodies were obtained as follows: Article Title: Coordinated regulation of chromatin modifiers reflects organised epigenetic programming in mouse oocytes Article Snippet: KDM6A , Rabbit , 1:400 , Validated in Article Title: Therapeutic targeting of histone lysine demethylase KDM4B blocks the growth of castration-resistant prostate cancer. Article Snippet: Following antibodies were used: pmTOR, mTOR, pS6, S6 kinase, KDM4B, Histone 3, cleaved PARP1, KDM6A, and |
![Kdm6a KO leads to increased gene expression from the Xi in differentiated cells. A Allelic X-linked gene expression ratios (129:cast) in Tsix -stop wt, CRISPR control, and KO cells ( Tsix-Kdm6a ΔEΔE17 and Tsix-Kdm6a ΔEΔE21 ) at D0 and D15 of differentiation. Ratios between expressed X-linked genes (> 1TPM) are shown. There is increased gene expression from the 129 X-chromosome (Xi) following Kdm6a KO differentiation. B, C Plots of expression from the Xi (B) and the Xa (C) (average for Tsix-Kdm6a ΔEΔE17 and Tsix-Kdm6a ΔEΔE21 ) at D15. Kdm6a and the XIC are highlighted. Log 2 TPM fold change (KO/wt) is shown. Genes with a decrease of expression in KO versus wt are in blue, and with an increase in red. Gene expression from the Xi is selectively increased following KO. D Top, scatter plots of average log 2 expression between Tsix- stop wt and KO clones (average for Tsix-Kdm6a ΔEΔE17 and Tsix-Kdm6a ΔEΔE21 ) at D15 for X-linked genes categorized as those silenced early, silenced at an intermediate time, silenced late, and not silenced (escape) during XCI [ , ]. KO clones show higher expression of genes in each category compared to wt. n indicates the number of genes in each category. Bottom, histograms of median allelic expression of genes silenced at different times during XCI and of genes that escape XCI is increased in Tsix- stop KO clones compared to wt and CRISPR controls for all categories, while there is little change in expression from the Xa. n indicates the number of genes in each category. E Expression fold changes of individual escape genes from the Xi in Tsix- stop KO clones (average for Tsix-Kdm6a ΔEΔE17 and Tsix-Kdm6a ΔEΔE21 ) compared to wt at D15. Most genes show increased expression](https://pub-med-central-images-cdn.bioz.com/pub_med_central_ids_ending_with_9772/pmc11699772/pmc11699772__13293_2024_683_Fig2_HTML.jpg)
